Collagen solubility correlates with skin optical clearing.

Publication Type:

Journal Article

Source:

Journal of biomedical optics, Volume 11, Issue 4, p.040501 (2006)

Keywords:

Animals, Collagen, Dermatologic Agents, Humans, Light, Rats, Refractometry, Scattering, Radiation, Skin, Skin Absorption, Solubility, Statistics as Topic

Abstract:

Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.

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