Publication Type:Journal Article
Source:Journal of biomedical optics, Volume 11, Issue 4, p.040501 (2006)
Keywords:Animals, Collagen, Dermatologic Agents, Humans, Light, Rats, Refractometry, Scattering, Radiation, Skin, Skin Absorption, Solubility, Statistics as Topic
Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.