Near-infrared-activated gold nanoshells for thermal ablation of macrophages in vitro

Publication Type:

Journal

Source:

Photonic Therapeutics and Diagnostics VI, Volume 7548 (2010)

Abstract:

In vitro studies were initiated to determine the suitability of murine and rat macrophages as delivery vehicles for gold
nanoshells in the treatment of gliomas. Visualization of macrophage accumulation in and around gliomas may be
accomplished using magnetic resonance imaging (MRI) and superparamagnetic iron oxide nanoparticles (SPIO). The
optimal loading of both murine and rat macrophages with SPIO was determined using inductively coupled plasma
atomic emission spectroscopy (ICP-AES). Higher concentrations of SPIO were observed in rat macrophages and the
optimal concentration in these cell lines was around 300 μg/ml. Higher concentrations resulted in significant cell
toxicity. SPIO were visualized in fixed rat brains subjected to high field MRI using T2*-weighted gradient echo pulse
sequences. Macrophages were found to be very sensitive to near infra-red (NIR) laser irradiation.

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