5-Aminolevulinic acid-based photodynamic detection and therapy of brain tumors (review).

Publication Type:

Journal Article

Source:

International journal of oncology, Volume 21, Issue 3, p.577-82 (2002)

Keywords:

Aminolevulinic Acid, Animals, Brain Neoplasms, Clinical Trials as Topic, Combined Modality Therapy, Humans, Photochemotherapy, Photosensitizing Agents

Abstract:

With current treatment methods the prognosis for patients with aggressive brain tumors is dismal. Treatment failure is usually due to local recurrence of tumor. Intra-operative photodynamic detection (PDD) of tumor tissue and post-surgical photodynamic therapy (PDT) of the resection cavity may be of benefit. The utility of 5-aminolevulinic acid (ALA) has been recognized in many different treatment fields over the past decade. Following administration of exogenous ALA, the endogenous photosensitizer, protoporphyrin IX (PpIX), accumulates in tumor tissue. A photodynamic effect occurs upon light activation of the target tissue. This article reviews the current preclinical and clinical studies and potential future applications of ALA and its ester-induced PpIX as a photosensitizing agent in the detection and treatment of brain tumors.